Mitochondrial stress can lead to structural alterations of mitochondria. In this study the authors examined the role of mitochondrial stress by studying stress response in mice having a myopathy caused by a dominant p.G58R mutation in the mitochondrial protein CHCHD10. Using our 3dEMtrace pipeline the authors could pinpoint the difference in structure of mitochondria in large volume electron microscopy datasets between mice positive and negative for OMA1 a stress mediating inner mitochondrial membrane peptidase.

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