Analyzing Hepatic Cell Architecture in Metabolic Research
In their work “Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity." published in Nature Communications, researchers around Günes Parlakgül investigated the spatial architecture of hepatic endoplasmic reticulum (ER) and mitochondria, focusing on their remodeling in fasting and obesity. By employing high-resolution volume electron microscopy, they discovered significant zonated remodeling of these organelles. This research provided valuable insights into the dynamic interplay between ER and mitochondria, crucial for understanding metabolic adaptations in response to nutritional states. The study utilized ariadne.ai’s 3dEMTrace pipeline for automated image segmentation, enabling accurate and detailed mapping of cellular structures. This technological integration facilitated an in-depth analysis of cellular responses, advancing our knowledge of metabolic processes.
Read the full publication here: https://www.nature.com/articles/s41467-024-48272-7